Protein Purification and Isolation Market by Product (Instruments, Consumables, Software), Technique (Ultrafiltration, Precipitation, Chromatography, Western Blotting), Application (Drug Screening, Target Identification), End User - Global Forecast to 2032

The Protein Purification and Isolation Market is projected to reach $15.04 billion by 2032, at a CAGR of 9.1% from 2025 to 2032. Protein purification is a process that isolates and purifies a single protein or protein complex from tissues, cells, or entire organisms. This process is essential for determining the cells' function, structure, and interactions of a protein of interest. Protein isolation helps understand the protein’s size, biological activity, binding affinity, protein-protein interaction, and physiochemical properties. Protein purification and isolation are done using various technologies such as precipitation, ultrafiltration, chromatography, and electrophoresis.

The growth of the protein purification and isolation market is driven by the growing need to identify new protein-based drug molecules, rising research in pharmaceutical and biopharmaceutical fields, and increasing focus on precision medicine. The increasing demand for protein therapeutics and rising spending on R&D in pharmaceutical and biotechnology industries are creating opportunities for the growth of this market.

Technological Advancements Boost the Growth of the Protein Purification and Isolation Market

Market players are focusing on developing innovative technologies for protein purification. For instance, in January 2022, QIAGEN N.V. (Germany) launched its QIAwave product line, which includes three nucleic acid extraction kits with fewer components. These products were developed to overcome the persistent problem of laboratory waste that scientists worldwide experience. These methods isolate and process DNA, RNA, and proteins from blood, tissues, and other sources. Compared to QIAGEN’s standard kits, these kits utilize up to 63% less plastic and 42% less cardboard.

In April 2021, Thermo Fisher Scientific Inc. (U.S.) launched its KingFisher Apex Purification System, a high-protein sample purification instrument for scientists to extract DNA, proteins, and cells. This system helps in protein and cell isolation and offers a highly customized process for adaptable, reproducible, and quick sample preparation at no extra cost. It generates error-free reports and high-quality nucleic acids and proteins with the help of automation technology. This protein purification device can process 24 to 96 samples in 25 to 65 minutes.

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Rising Government Spending on Research & Development in Pharmaceutical and Biotechnology Creates an Opportunity for the Market

Increased government spending on R&D and initiatives to strengthen pharmaceutical and biotechnology sectors contribute to the growth of this market. According to the Indian Brand Equity Foundation (IBEF), the Indian government allocated USD 10.35 billion, and the Department of Health Research allocated USD 365.68 billion to promote the pharmaceutical sector in the Union Budget 2021–22. Additionally, as per the data published by the U.K. parliament in March 2022, the government declared R&D budget for 2022–25 was USD 41.9 million (EUR 39.8 billion). Under these plans, spending will rise from USD 5.3 million (EUR 5 billion) to USD 21.1 million (EUR 20 billion) annually from 2020 to 2025.

Key Findings in the Global Protein Purification and Isolation Market study:

In 2025, the Consumables Segment is Expected to Account for the Largest Share of this Market

Based on product, in 2025, the consumables segment is expected to account for the largest share of the protein purification and isolation market. This segment is further segmented into protein purification kits, reagents, prepacked columns, protein purification resins, magnetic beads, and other consumables. The large market share of this segment is mainly attributed to the recurring use of consumables for protein purification and the focus of various end users, such as academic & medical research institutes and pharmaceutical companies, on developing biopharmaceuticals.  

In 2025, the Chromatography Segment is Expected to Account for the Largest Share of this Market

Based on technique, in 2025, the chromatography segment is expected to account for the largest share of the protein purification and isolation market. Chromatography is one of the most accurate and sensitive protein isolation and purification techniques. The use of chromatography for protein purification ensures protein extraction at sufficient purity in a cost-effective way, owing to which the adoption of this technique is higher.  

In 2025, the Protein-Protein Interaction Studies Segment is Expected to Account for the Largest Share of this Market

Based on application, in 2025, the protein-protein interaction segment is expected to account for the largest share of the protein purification and isolation market. Protein-protein interaction predicts the druggability of molecules and the protein function of the target protein. The rise in the number of structural protein-based investigations due to the increase in focus on developing biopharmaceuticals is a key factor supporting the large market share of this segment.

The Academic & Research Institutes Segment is Projected to Register the Highest CAGR

The academic & research institutes segment is projected to register the highest CAGR over the forecast period. Growing research initiatives in academic institutes for structural and functional protein engineering and increasing use of protein purification techniques in discovering novel therapeutics are the factors driving the growth of this segment.

Asia-Pacific: Fastest Growing Regional Market

The growth of this market is driven by the changing healthcare infrastructure in developing countries, rising healthcare spending, growing demand for biosimilars, and developing infrastructure for medical research. Additionally, the high volume of production of biosimilars and initiatives promoting the domestic production of pharmaceuticals also support the market growth.

Key Players

The report includes a competitive landscape based on an extensive assessment of the key strategic developments adopted by key market players in the past three to four years. The key players profiled in the global protein purification and isolation market report are Thermo Fisher Scientific Inc.(U.S.), Bio-Rad Laboratories, Inc. (U.S.), Merck KGaA (Germany), QIAGEN N.V. (Germany), Danaher Corporation (U.S.), Agilent Technologies, Inc. (U.S.), Promega Corporation (U.S.), F. Hoffmann-La Roche Ltd (Switzerland), BioVision Inc.(U.S.), Norgen Biotek Corporation (Canada), and Sartorius AG (Germany).

Scope of the Report

Protein Purification and Isolation Market, by Product

• Instruments
• Consumables
  • Protein Purification Kits
  • Reagents
  • Prepacked Columns
  • Protein Purification Resins
  • Magnetic Beads
    • Tagged Magnetic Beads
    • Non-tagged Magnetic Beads
  • Other Consumables
    (Note: Other consumables include plastic ware, filters, chromatography solvents, and standards for chromatography and electrophoresis)
• Software

Protein Purification and Isolation Market, by Technique

• Ultrafiltration
• Precipitation
• Chromatography
  • Liquid Chromatography
  • Ion Exchange Chromatography
  • Affinity Chromatography
    • Immobilized Metal Ion Chromatography (IMAC)
    • Immunoaffinity Chromatography (IAC)
    • Bead-based Chromatography
  • Reversed-phase Chromatography (RPC)
  • Hydrophobic Interaction Chromatography (HIC)
  • Size-exclusion Chromatography (Gel Filtration)
• Electrophoresis
  • Gel Electrophoresis
  • Isoelectric Focusing
  • Capillary Electrophoresis
• Western Blotting (Immunoblotting)
• Dialysis and Diafiltration
• Centrifugation
• Other Techniques
  (Note: Other techniques include mass spectroscopy and enzyme-linked immunosorbent assay (ELISA))

Protein Purification and Isolation Market, by Application

• Protein-protein Interaction Studies
• Drug Screening
• Target Identification
• Protein Therapeutics
• Disease Diagnostics and Monitoring
• Other Applications
  (Note: Other applications include disease diagnostics and monitoring and biomarker discovery)

Protein Purification and Isolation Market, by End User

• Academic & Research Institutes
• Hospitals and Diagnostics Centers
• Pharmaceutical and Biotechnology Companies
• Contract Research Organizations (CROs)
• Other End Users
  (Note: Other end users include food, cosmetic, and agriculture industries)

Protein Purification and Isolation Market, by Geography

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • U.K.
  • France
  • Italy
  • Spain
  • Rest of Europe (RoE)
• Asia-Pacific
  • China
  • Japan
  • India
  • Rest of APAC (RoAPAC)
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America (RoLATAM)
• Middle East & Africa

Key questions answered in the report: