DNA sequencing is a method used to determine the exact sequence of nucleotides in DNA molecules. It facilitates understanding the function of genes and other parts of the genome. Some of the notable DNA sequencing technologies are next-generation sequencing, Sanger sequencing, and third & fourth-generation sequencing.
Advancements in Sequencing Technologies: Portable and Benchtop Sequencers
The ability to sequence the genes of any organism for clinical and research conclusions has proved to be a game changer for public health. Portable handheld sequencing devices are paving the way for the future growth of this market by making sequencing cheaper, simpler, and faster without the need for large clinical laboratory settings. Real-time sequencing has enabled researchers and physicians to quickly access sequencing data and act instantly. Portable nanopore-based sequencers can sequence the entire genome in less than USD 1,000. The devices pass the DNA molecule through a pore within a small protein called a nanopore that is embedded within the membrane. The DNA molecule then passes through the nanopore, connecting the template and the complementary strand to the adaptor.
Real-time sequencing is increasingly being used in applications such as disease characterization, contaminant detection, and plant genome analysis. For instance, Ginkgo Bioworks, a Boston-based biotech company, utilized the MinION nanopore sequencing device to detect toxic contaminants in a culture, enabling operators to remove the harmful components and save the culture. Additionally, scientists in Madagascar recently conducted DNA sequencing for the first time in the country using portable technology, which allowed them to rapidly identify the bacteria causing tuberculosis (TB) and assess its drug resistance profile.
Active Research in Genomics and Proteomics
During the last decade, active research in genomics and proteomics has increased, mainly due to technological advancements and the need to understand the genetic and molecular makeup of various diseases. Traditionally, the conventional Sanger sequencing technology, which could sequence and analyze single genes, amplicon targets, genomic fragments, and short tandem repeats, was used in proteomics and genomics research. However, according to the National Human Genome Research Institute, Sanger sequencing can produce inaccurate results in many cases, provide low throughput, and be time-consuming. Hence, it has recently been replaced by Next-Generation Sequencing (NGS), which can analyze 100 genes simultaneously, needs a low amount of input, and is significantly more cost-effective. Sanger sequencing costs about USD 500 per 1,000 bases, whereas NGS costs USD 0.50 per 1,000 bases. Thus, active research in genomics and proteomics is increasing the demand for advanced DNA sequencing solutions to obtain more precise and fruitful samples.
DNA Sequencing Market Analysis
Recent insights from Meticulous Research® provide valuable perspectives on the future trajectory of the DNA Sequencing Industry. Projections suggest a potential worth of $21.30 billion by 2031, driven by a robust Compound Annual Growth Rate (CAGR) of 11.8% from 2024 to 2031.
As the global landscape evolves, North America is expected to maintain a substantial market share in 2024. Prominent industry players such as Illumina, Inc. (U.S.), Thermo Fisher Scientific, Inc. (U.S.), MGI Tech Co., Ltd. (China), and Agilent Technologies, Inc. (U.S.) have established a significant presence across various regions. Their extensive reach and the widespread adoption of their sample preparation technologies for diagnostics and research purposes contribute to this dominance. This comprehensive overview from Meticulous Research provides valuable insights into the DNA sequencing market.
Conclusion
The increasing global focus on genetic research has driven the demand for advanced DNA sequencing solutions. Moreover, the use of cutting-edge technologies in diagnosing diseases is transforming treatment approaches, making them more effective and precise.
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