The field of genomics has surpassed expectations over the past three decades due to advancements in sequencing, resulting in increased efficiency and accuracy for genetic analysis. Next-generation sequencing (NGS) is a technology used to sequence the orientation of nucleotides in genetic material. This technology enables the sequencing of DNA or RNA more precisely, allowing researchers to decode genetic information at an unprecedented scale and speed.
Advancements in Sequencing Technologies: Portable and Benchtop Sequencers
The ability to sequence the genes of any organism for clinical and research conclusions has revolutionized health diagnosis & treatment. Portable handheld sequencing devices have made sequencing cheaper, simpler, and faster without the need for large clinical laboratory settings. Real-time sequencing has enabled researchers and physicians to quickly access sequencing data and act instantly. Portable nanopore-based sequencers can sequence the entire genome in less than USD 1,000. The devices pass the DNA molecule through a pore within a small protein called a nanopore that is embedded within the membrane. The DNA molecule then passes through the nanopore, connecting the template and the complementary strand to the adaptor.
Real-time sequencing is increasingly finding applications in disease characterization, contaminant detection, and plant genome analysis. For instance, Boston-based biotech company Ginkgo Bioworks utilized the MinION nanopore sequencing device to detect toxic contaminants in a culture, enabling timely removal of harmful components and preserving the culture. Additionally, scientists in Madagascar recently conducted DNA sequencing within the country for the first time using portable technology, swiftly identifying the bacteria responsible for tuberculosis (TB) and its drug resistance profile.
Active Research in Genomics and Proteomics
During the last decade, active research in genomics and proteomics has increased, mainly due to technological advancements and the need to understand the genetic and molecular makeup of various diseases. Traditionally, the conventional Sanger sequencing technology, which could sequence and analyze single genes, amplicon targets, genomic fragments, and short tandem repeats, was used in proteomics and genomics research. However, according to the National Human Genome Research Institute, Sanger sequencing can produce inaccurate results in many cases, provide low throughput, and be time-consuming. Hence, it has recently been replaced by Next-Generation Sequencing (NGS), which can analyze 100 genes simultaneously, needs a low amount of input, and is significantly more cost-effective. Sanger sequencing costs about USD 500 per 1,000 bases, whereas NGS costs USD 0.50 per 1,000 bases. Thus, increasing research efforts in genomics and proteomics are driving the demand for advanced next-generation sequencing solutions to obtain more precise and fruitful samples.
Next-Generation Sequencing (NGS) Market Analysis
Recent insights from Meticulous Research® provide valuable perspectives on the future trajectory of the next-generation sequencing (NGS) market. Projections suggest a potential worth of $42.7 billion by 2031, at a Compound Annual Growth Rate (CAGR) of 15.7% from 2024 to 2031.
As the global landscape takes shape, the North American region is expected to hold a substantial market share in 2024. Notably, influential industry players, including Illumina, Inc. (U.S.), Thermo Fisher Scientific, Inc. (U.S.), MGI Tech Co., Ltd. (China), Agilent Technologies, Inc. (U.S.), and other major players have established a broad presence across various regions, leading to the widespread adoption of their sample preparation for several diagnostics and research purposes. This comprehensive overview from Meticulous Research® serves as a gateway into the next-generation sequencing (NGS) market.
Conclusion
The rising focus on genetic research globally has propelled the demand for advanced next-generation sequencing (NGS) solutions. Additionally, diagnoses of diseases facilitated using advanced technologies are reshaping the approach towards treatment of several infectious and other diseases, making it more effective and precise.
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