The field of genomics has surpassed expectations over the past three decades due to massive advancements in sequencing technologies that allowed researchers to interrogate larger pieces of the human genome. Genome or DNA sequencing using technologies such as Sanger, NGS, nanopore, and SMRT helps identify the sequence of nucleotides in DNA/RNA. Due to technological advancements, low–cost, precise, and quick response, sequencing the genome enables deeper insights for clinical and research purposes.
Advancements in Sequencing Technologies: SMRT & Nanopore Sequencing
The ability to sequence the genes of any organism for clinical and research conclusions has proved to be a game changer for public health. Portable handheld sequencing devices are paving the way for the future growth of the sequencing kits market by making sequencing cheaper, simpler, and faster without the need for large clinical laboratories. Real-time sequencing has enabled researchers and physicians to quickly access sequencing data and act instantly. Portable nanopore-based sequencers can sequence the entire genome in less than USD 1,000. The devices pass the DNA molecule through a pore within a small protein called a nanopore that is embedded within a membrane. The DNA molecule then passes through the nanopore, connecting the template and the complementary strand to the adaptor. The connection of the strand with the adaptor initiates an electric current, which is typically recorded and represented in the form of a graph.
Real-time sequencing is gradually being adopted in applications, including disease characterization, contaminant detection, and plant genome analysis. For instance, Boston-based biotech company Ginkgo Bioworks used the MinION nanopore sequencing device to detect toxic contaminants in a culture and alerted the operators to remove toxic components, saving the culture. Also, for the first time, scientists in Madagascar performed DNA sequencing in the country using portable technology to rapidly identify the bacteria responsible for tuberculosis (TB) and its drug resistance profile. Such advancements in sequencing technologies with expanding application areas have further increased the demand for advanced sequencing kits, triggering the growth of the market.
Also, portable sequencing devices were recently proven useful in the early detection of the Ebola and Zika viruses. According to Cornell University (U.S.), portable sequencers offer several advantages over benchtop sequencers. Portable sequencers are inexpensive, mobile, handy, and designed to be easily operated in the field. Moreover, they use the biochemical principle, which enables real-time streaming of the raw signal as soon as DNA molecules are sensed.
From Sequencing to Actionable Insights: The Power of NGS
The use of advanced sequencing technologies, including next-generation sequencing (NGS), has increased in several clinical and research applications such as drug discovery, agriculture & animal research, reproductive health, and infectious diseases, among others, due to their high accuracy and declining sequencing costs.
NGS technology enables the rapid and reliable sequencing of multiple genes simultaneously. NGS has helped advance precision medicine, which involves tailoring treatments based on disease-causing molecular changes in a person's body. While NGS is used in various scenarios, researchers currently use it for sequencing patient’s biopsy samples to determine the right medicines to target the genetic abnormalities driving tumor growth.
Furthermore, NGS has shown promising results in reproductive health, agricultural, and animal research due to the decreasing costs and turnaround times of NGS, improvements in bioinformatics analyses, and the harmonization of knowledge bases to facilitate the clinical interpretation of genomic results. Such technological advancements have further improved how researchers decide the treatment pathway based on insights gained from sequencing.
High Growth Potential in Emerging Economies
The advent of advanced sequencing technologies such as NGS, nanopore, and SMRT, increasing cancer cases, and increasing healthcare expenditure presents significant growth opportunities for the players operating in the sequencing kits market.
China, Japan, India, and Singapore aim to gain a strategic position in the global biotech market, paving the way for many research and development activities. India and China are well-established markets in the global biotech outsourcing industry. Compared to western countries, India and China's large, skilled, and inexpensive workforce has given the countries an advantage in furthering the growth of their biotech industries.
Prominent market players are directing their attention towards the Asia-Pacific region, which is emerging as a dynamic market for healthcare product manufacturers and service providers due to continuous improvements in its healthcare infrastructure. Additionally, the substantial population growth in Asia-Pacific stands out as the pivotal factor propelling the growth of the healthcare and pharmaceutical sectors in the region, attracting investments from private and public organizations.
Ahead of the Curve: Sequencing Kits Market Analysis
Recent insights from Meticulous Research® provide valuable perspectives on the future trajectory of the Sequencing Kits Market. Projections suggest a potential worth of $25.29 billion by 2031, driven by a remarkable Compound Annual Growth Rate (CAGR) of 15.5% from 2024 to 2031. At the heart of this transformation is NGS, an advanced technology employed to sequence the orientation of nucleotides in genetic material. Its increasing applications are reshaping various aspects, from cancer research to agricultural and animal research.
Significant trends are emerging due to the ongoing evolution of the sequencing kits market. In 2023, the technologies used for sequencing have emerged as an important aspect, propelled by the demand for gaining accurate and precise insights for determining the treatment pathway. Additionally, insights address multiple questions critical for precise disease treatment, including diagnosis.
As the global landscape takes shape, the North American region is expected to hold a substantial market share in 2024. Notably, influential industry players, including Thermo Fisher Scientific Inc. (U.S.), Illumina, Inc. (U.S.), and F. Hoffmann-La Roche Ltd. (Switzerland), have established a broad presence across various regions, leading to the widespread adoption of their sequencing kits for several clinical and research purposes. In essence, this comprehensive overview from Meticulous Research serves as a gateway into the sequencing kits market.
Conclusion
The rise in demand for precision medicine globally has propelled the demand for advanced sequencing solutions. Additionally, diagnoses of diseases facilitated using advanced technologies are reshaping the approach towards treatment of several genetic, infectious, and inherited diseases, making it more effective and precise.
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